GLP-1 medicines can potentially exacerbate heartburn or acid reflux symptoms in some individuals. Since these medications slow gastric emptying, they may increase the likelihood of acid reflux or heartburn, especially shortly after meals. If you have a history of acid reflux or GERD, it's essential to monitor your symptoms closely after starting GLP-1 therapy. Making dietary adjustments, such as avoiding spicy or fatty foods, and consulting with your healthcare provider can help manage these symptoms effectively. If heartburn persists, your doctor may suggest alternative treatments or adjustments to your medication regimen.